Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13

H O Molhuizen; P L Zeeuwen; D Olde Weghuis; A Geurts van Kessel; J Schalkwijk

doi:10.1159/000133683

Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13

Cytogenet Cell Genet. 1994;66(2):129-31. doi: 10.1159/000133683.

Authors

H O Molhuizen¹, P L Zeeuwen, D Olde Weghuis, A Geurts van Kessel, J Schalkwijk

Affiliation

¹ Department of Dermatology, University Hospital Nijmegen, The Netherlands.

PMID: 8287685
DOI: 10.1159/000133683

Abstract

Recently we isolated a cDNA clone corresponding to an epidermal serine proteinase inhibitor named SKALP (skin-derived antileukoproteinase). Here we report the chromosomal localization of the human gene encoding SKALP by Southern blot analysis of a panel of human x hamster hybrid cell lines and by nonradioactive in situ hybridization on R-banded human lymphocyte chromosome spreads. The SKALP-encoding gene has been assigned the approved symbol PI3 by the Human Gene Mapping nomenclature committee.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping
Chromosomes, Human, Pair 20*
Cricetinae
Elafin
Epidermis / enzymology*
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Proteinase Inhibitory Proteins, Secretory
Proteins*
Serine Proteinase Inhibitors / genetics*

Substances

Elafin
PI3 protein, human
Proteinase Inhibitory Proteins, Secretory
Proteins
Serine Proteinase Inhibitors