Abstract
A new cytotoxic aromatic alkaloid, pantherinine [1], and a mixture of nucleosides including 7-deazainosine [3], have been isolated from the ascidian Aplidium pantherinum collected at Stenhouse Bay, South Australia. The structures were determined primarily from 1H- and 13C-nmr data, especially one-bond and multiple-bond proton-carbon correlations. Although 7-deazainosine [3] has been known as a synthetic compound for several decades, this appears to be the first report of its isolation as a natural product.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acridines / isolation & purification*
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Acridines / pharmacology
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Quinolones / isolation & purification*
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Quinolones / pharmacology
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South Australia
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Urochordata / chemistry*
Substances
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Acridines
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Antineoplastic Agents
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Quinolones
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pantherinine