Synthesis and characterization of a penicillin-poly(L-lysine) which recognizes human IgE anti-penicillin antibodies

Bioconjug Chem. 1993 Sep-Oct;4(5):309-13. doi: 10.1021/bc00023a001.

Abstract

Conjugates of poly(L-lysine) containing a penicillin or a penicilloyl residue were prepared and characterized by 1H NMR and by size-exclusion HPLC. These conjugates and conjugates with human serum albumin were used in radioallergosorbent tests (RAST) for the determination of allergy toward penicillins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / immunology*
  • Chromatography, High Pressure Liquid
  • Hydrogen-Ion Concentration
  • Immunoglobulin E / immunology*
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Penicillin G / immunology
  • Penicillins / chemical synthesis*
  • Penicillins / immunology
  • Polylysine / chemical synthesis*
  • Polylysine / immunology
  • Radioallergosorbent Test
  • Serum Albumin / chemistry
  • Serum Albumin / immunology

Substances

  • Antibodies
  • Indicators and Reagents
  • Penicillins
  • Serum Albumin
  • Polylysine
  • Immunoglobulin E
  • Penicillin G