[Analgesic effect and gastro-intestinal motility inhibitory action of 3-hydroxy-4-methoxy-acetophenone from Cynanchum paniculatum (Bunge) Kitagawa]

Zhongguo Zhong Yao Za Zhi. 1993 Jun;18(6):362-3, 383.
[Article in Chinese]

Abstract

3-Hydroxy-4-methoxy-acetophenone (HMA) isolated from Cynanchum paniculatum was found to have analgesic effect and inhibitory action on the gastro-intestinal motility. The effect and action were equivalent to that of paeonol, HMA displayed a very low degree of antibacterial activity against Escherichia coli and Shigella flexneri.

MeSH terms

  • Acetophenones / isolation & purification
  • Acetophenones / pharmacology*
  • Analgesics / pharmacology*
  • Animals
  • Drugs, Chinese Herbal / chemistry*
  • Escherichia coli / drug effects
  • Female
  • Gastrointestinal Motility / drug effects*
  • Male
  • Mice
  • Pain Threshold / drug effects*
  • Shigella flexneri / drug effects

Substances

  • Acetophenones
  • Analgesics
  • Drugs, Chinese Herbal
  • 3-hydroxy-4-methoxyacetophenone
  • paeonol