The authors studied a group of 77 patients with Erythema migrans. They were treated at the City Institute for Skin and Venereal Disease in Belgrade, over a five-year period (1988-1992). A tick bite at the site where Erythema migrans later appeared was recalled by 44 (57.1%) of the patients. The interval between tick bite and Erythema migrans varied from 1 to 45 days. The indirect IF test was seropositive in 11.6% of the Erythema migrans patients. In the present study the authors emphasize the importance of early treatment in order to minimize the longterm morbidity.