Abstract
The [Pt(pyr)(N-Etlm)Cl4] complex, where pyr = pyrimidine and N-Etlm = N-ethylimidazole, previously prepared and characterized, showed an interesting cytotoxicity in vitro on the human ovarian carcinoma (A2780) and on his subline resistant to cis-platinum (A2780/CDDP), in comparison with cis-platinum and carboplatinum.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carboplatin / pharmacology
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Cisplatin / pharmacology
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Drug Screening Assays, Antitumor
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Female
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Humans
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Leukemia / drug therapy
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Mice
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Organoplatinum Compounds / pharmacology*
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Ovarian Neoplasms / drug therapy
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Tumor Cells, Cultured
Substances
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Organoplatinum Compounds
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BBR 2889
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Carboplatin
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Cisplatin