The influence of antigen organization on B cell responsiveness

Science. 1993 Nov 26;262(5138):1448-51. doi: 10.1126/science.8248784.

Abstract

The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / biosynthesis*
  • Antibodies, Viral / immunology
  • Antibody Affinity
  • B-Lymphocytes / immunology*
  • Immune Tolerance*
  • Immunization
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Lymphocyte Activation
  • Macrophages, Peritoneal / microbiology
  • Membrane Glycoproteins*
  • Mice
  • Mice, Transgenic
  • Neutralization Tests
  • T-Lymphocytes, Helper-Inducer / immunology
  • Vesicular stomatitis Indiana virus / immunology*
  • Vesicular stomatitis Indiana virus / physiology
  • Viral Envelope Proteins / immunology*

Substances

  • Antibodies, Viral
  • G protein, vesicular stomatitis virus
  • Immunoglobulin G
  • Immunoglobulin M
  • Membrane Glycoproteins
  • Viral Envelope Proteins