Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity

Y Hayakawa; M Matsuoka; K Shin-ya; H Seto

doi:10.7164/antibiotics.46.1557

Quinolidomicins A1, A2 and B1, novel 60-membered macrolide antibiotics. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity

J Antibiot (Tokyo). 1993 Oct;46(10):1557-62. doi: 10.7164/antibiotics.46.1557.

Authors

Y Hayakawa¹, M Matsuoka, K Shin-ya, H Seto

Affiliation

¹ Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.

PMID: 8244883
DOI: 10.7164/antibiotics.46.1557

Abstract

Three novel macrolide antibiotics, quinolidomicins A1, A2 and B1, were isolated from the fermentation broth of Micromonospora sp. JY16. Quinolidomicin A1 inhibited the growth of various tumor cells including multidrug-resistant cells. Quinolidomicin B1 was similarly cytotoxic, while quinolidomicin A2 was inactive against these tumor cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / therapeutic use
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / therapeutic use
Fermentation
Humans
Leukemia P388 / drug therapy
Macrolides*
Magnetic Resonance Spectroscopy
Mice
Micromonospora / chemistry*
Tumor Cells, Cultured / drug effects

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Macrolides
quinolidomicin A2
quinolidomicin B1
quinolidomicin A1