Sound stimulation increases the cerebral glucose:oxygen quotient in the fetal sheep

Exp Physiol. 1993 Sep;78(5):707-10. doi: 10.1113/expphysiol.1993.sp003718.

Abstract

We sought to determine the cerebral metabolic fate of glucose during sound stimulation in near-term fetal sheep. Blood oxygen content was significantly decreased by 6-7% during sound stimulation. The cerebral glucose:oxygen quotient increased from 0.88 +/- 0.08 to 1.13 +/- 0.12 (mean +/- S.E.M., P < 0.01). This is consistent with the phenomenon of stimulated glycolysis which has been shown to increase brain lactate concentration in other models.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation*
  • Animals
  • Blood Gas Analysis
  • Cerebral Cortex / chemistry*
  • Cerebral Cortex / embryology
  • Cerebral Cortex / metabolism
  • Female
  • Fetus / chemistry*
  • Fetus / metabolism
  • Glucose / analysis*
  • Glucose / metabolism
  • Glycolysis / physiology
  • Oxygen / analysis*
  • Oxygen / metabolism
  • Pregnancy
  • Sheep / metabolism
  • Sheep / physiology*

Substances

  • Glucose
  • Oxygen