The beta A4 amyloid protein precursor in human circulation

A I Bush; K Beyreuther; C L Masters

doi:10.1111/j.1749-6632.1993.tb23048.x

The beta A4 amyloid protein precursor in human circulation

Ann N Y Acad Sci. 1993 Sep 24:695:175-82. doi: 10.1111/j.1749-6632.1993.tb23048.x.

Authors

A I Bush¹, K Beyreuther, C L Masters

Affiliation

¹ Department of Pathology, University of Melbourne, Victoria Australia.

PMID: 8239279
DOI: 10.1111/j.1749-6632.1993.tb23048.x

Abstract

beta A4, the principal constituent of the brain amyloid collections in Alzheimer's disease, is derived from a much larger precursor, the amyloid protein precursor (APP). APP exists in the blood as full-length, potentially amyloidogenic forms in platelets, and as an attenuated species in plasma and T-lymphocytes. Studies of circulating APP facilitate the elaboration of the function of this protein, as well as the elucidation of its processing in health and disease.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / blood
Alzheimer Disease / metabolism
Amyloid beta-Peptides / biosynthesis
Amyloid beta-Peptides / blood*
Amyloid beta-Protein Precursor / blood*
Amyloid beta-Protein Precursor / metabolism
Amyloidosis / metabolism
Blood Platelets / metabolism
Down Syndrome / metabolism
Humans
Lymphocytes / metabolism
Protein Processing, Post-Translational

Substances

Amyloid beta-Peptides
Amyloid beta-Protein Precursor