Protective effect of SV-IV on platelet-activating factor-induced hypotension, bronchoconstriction and gastric mucosal injury

Eur J Pharmacol. 1993 Sep 7;241(1):71-4. doi: 10.1016/0014-2999(93)90934-a.

Abstract

The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to prevent dose dependently both hypotension and acute bronchospasm caused by PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Blood Pressure / drug effects*
  • Bronchoconstriction / drug effects*
  • Dose-Response Relationship, Drug
  • Ethanol
  • Guinea Pigs
  • Male
  • Platelet Activating Factor / antagonists & inhibitors*
  • Platelet Activating Factor / pharmacology
  • Prostatic Secretory Proteins*
  • Proteins / pharmacology*
  • Rats
  • Rats, Wistar
  • Seminal Plasma Proteins
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / prevention & control

Substances

  • Anti-Ulcer Agents
  • Platelet Activating Factor
  • Prostatic Secretory Proteins
  • Proteins
  • Seminal Plasma Proteins
  • beta-microseminoprotein
  • Ethanol