Abstract
The inhibitory effect of one of the major proteins secreted by the rat seminal vesicles (SV-IV) on platelet-activating factor (PAF)-induced biological activities was investigated in vivo. SV-IV was found to prevent dose dependently both hypotension and acute bronchospasm caused by PAF administration in guinea-pigs. In addition, SV-IV inhibited both PAF- and ethanol-induced gastric mucosal injury in a dose-dependent manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Ulcer Agents / pharmacology*
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Blood Pressure / drug effects*
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Bronchoconstriction / drug effects*
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Dose-Response Relationship, Drug
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Ethanol
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Guinea Pigs
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Male
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Platelet Activating Factor / antagonists & inhibitors*
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Platelet Activating Factor / pharmacology
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Prostatic Secretory Proteins*
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Proteins / pharmacology*
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Rats
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Rats, Wistar
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Seminal Plasma Proteins
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Stomach Ulcer / chemically induced
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Stomach Ulcer / prevention & control
Substances
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Anti-Ulcer Agents
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Platelet Activating Factor
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Prostatic Secretory Proteins
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Proteins
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Seminal Plasma Proteins
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beta-microseminoprotein
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Ethanol