Aberration antigen expression in adult acute myelocytic leukemias

Chin Med J (Engl). 1993 Jun;106(6):419-22.

Abstract

Marrows from 58 newly diagnosed acute myelocytic leukemia (FAB-AML) patients were immunophenotyped by flow cytometry with 13 kinds of monoclonal antibodies. Marrows of 53.4% of the patients showed pure myeloid antigen expression (Ly-AML) and 34.5% displayed both myeloid and lymphocyte associated antigen expression (Ly+AML). In general, fluorescence intensity of lymphocyte associated antigen in Ly+AML was weaker than that of myeloid antigen. Myeloid and lymphoid marker cells distributed randomly in DNA-aneuploidy. It took more days to reach the first complete remission in Ly+AML. The aberration antigen expression in AML allows a sensitive detection of minimal residual leukemic cells in complete remission bone marrow and treatment stratification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / analysis*
  • Bone Marrow / immunology
  • Bone Marrow / pathology
  • Female
  • Flow Cytometry
  • HLA-DR Antigens / analysis
  • Humans
  • Immunophenotyping
  • Leukemia, Myeloid, Acute / immunology*
  • Male
  • Middle Aged
  • Neprilysin / analysis

Substances

  • Antigens, CD
  • HLA-DR Antigens
  • Neprilysin