Acute myocardial infarction complicating prothrombin complex concentrate therapy in an 8-year-old boy with hemophilia A and factor VIII inhibitor

Am J Pediatr Hematol Oncol. 1993 Nov;15(4):416-9.

Abstract

Purpose: An 8-year-old boy with mild hemophilia A and inhibitors developed an acute myocardial infarction during treatment with prothrombin complex concentrates.

Conclusions: This rare complication warrants restriction of dosage and length of treatment with these products to the recommended guidelines. It also appears that noninvasive cardiac monitoring of these patients is beneficial.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Blood Coagulation Factors / adverse effects*
  • Blood Coagulation Factors / therapeutic use*
  • Child
  • Factor VIII / antagonists & inhibitors*
  • Hemophilia A / therapy*
  • Humans
  • Male
  • Myocardial Infarction / chemically induced*

Substances

  • Blood Coagulation Factors
  • prothrombin complex concentrates
  • Factor VIII
  • anti-inhibitor coagulant complex