The problem of deciding which journal titles to select for acquisition in a biomedical library is modeled. The approach taken is based on cost/benefit ratios. Measures of journal worth, methods of data collection, and journal cost data are considered. The emphasis is on the development of a practical process for selecting journal titles, based on the objectivity and rationality of the model; and on the collection of the approprate data and library statistics in a reasonable manner. The implications of this process towards an overall management information system (MIS) for biomedical serials handling are discussed.