Effect of genetically determined host factors on the efficacy of vidarabine, acyclovir and 5-trifluorothymidine in herpes simplex virus type 1 infection

Ophthalmic Res. 1994;26(2):95-104. doi: 10.1159/000267398.

Abstract

The susceptibility of Herpes simplex virus (HSV) to acyclovir (ACV), 5-trifluorothymidine (TFT) and vidarabine (Ara-A) in HSV-infected embryo fibroblasts from BALB/c and C57BL/6 mice as well as Vero cells were measured. Ara-A and TFT (at its highest concentration) were more effective in Vero cells and BALB/c mouse embryo fibroblasts (MEF) than in C57BL/6 MEF. In contrast, ACV was more effective in C57BL/6 MEF than BALB/c MEF and Vero cells. These data suggest that genetically determined differences in the ability of host cells to support the replication of HSV influence the activity of antiviral drugs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyclovir / pharmacology*
  • Animals
  • Embryo, Mammalian / microbiology
  • Female
  • Fibroblasts / microbiology
  • Genetic Variation*
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / physiology
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Pregnancy
  • Trifluridine / pharmacology*
  • Vero Cells
  • Vidarabine / pharmacology*
  • Virus Replication / genetics
  • Virus Replication / physiology*

Substances

  • Vidarabine
  • Trifluridine
  • Acyclovir