Abstract
A VLDL-like particle containing the apo B100-apo(a) complex was isolated from the post-prandial plasma of subjects fed a fat meal enriched in saturated fatty acids. The abundance of this lipoprotein particle, that we call TG-Lp(a), varied among subjects but not in the same subject. TG-Lp(a), but not the classic Lp(a), contained apo E; this apolipoprotein may cause divergence in cellular uptake and degradation between these two classes of lipoproteins.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Apolipoprotein B-100
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Apolipoproteins B / metabolism
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Apolipoproteins E / metabolism*
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Dietary Fats / administration & dosage
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Eating
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Fatty Acids / administration & dosage
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Humans
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Hypolipoproteinemias / blood
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Lipoprotein(a) / blood*
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Lipoprotein(a) / chemistry
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Lipoproteins, HDL / blood
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Lipoproteins, HDL / deficiency
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Lipoproteins, VLDL / blood
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Male
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Triglycerides / blood*
Substances
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Apolipoprotein B-100
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Apolipoproteins B
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Apolipoproteins E
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Dietary Fats
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Fatty Acids
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Lipoprotein(a)
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Lipoproteins, HDL
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Lipoproteins, VLDL
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Triglycerides