Tactile and pain thresholds were determined in 116 patients 24 hours before surgery upon premedication and administration of fentanyl and droperidol during induction to anesthesia. Statistical correlation analysis has shown that high pain thresholds in patients 24 hours before surgery indicate low consumption of barbiturates during induction to anesthesia, high efficacy of drugs used for NLA, and infrequent reactions to intubation irrespective of the efficacy of premedication. Low pain thresholds after premedication predict low efficacy of drugs for NLA and high consumption of fentanyl during surgery.