167-A, a new antibiotic produced by a mutant of an inactive wild strain of Amycolata autotrophica

J Antibiot (Tokyo). 1994 Mar;47(3):342-8. doi: 10.7164/antibiotics.47.342.

Abstract

Two related antibiotics, 167-A and 167-B, were isolated from the fermentation broth of a mutant of an inactive wild strain of Amycolata autotrophica. Antibiotic 167-B was found to be cervinomycin A2; antibiotic 167-A is a new representative of the same group and has the structure of 18-O-demethyl cervinomycin A2.

MeSH terms

  • Actinomycetales / classification
  • Actinomycetales / metabolism*
  • Anthracyclines*
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / classification
  • Anti-Bacterial Agents* / isolation & purification
  • Anti-Bacterial Agents* / pharmacology
  • Antibiotics, Antineoplastic* / biosynthesis
  • Antibiotics, Antineoplastic* / chemistry
  • Antibiotics, Antineoplastic* / isolation & purification
  • Antibiotics, Antineoplastic* / pharmacology
  • Fermentation
  • Gram-Positive Bacteria / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Mutagenesis

Substances

  • 18-O-demethylcervinomycin A2
  • Anthracyclines
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • cervinomycin A2