Active expectant management in very early gestations complicated by premature rupture of the fetal membranes

J Reprod Med. 1994 Jan;39(1):13-6.

Abstract

Premature rupture of the membranes (PROM) in the previable gestation is frequently associated with fetal or neonatal death. Passive expectant management is successful in only a small minority of cases. Women presenting with PROM at < or = 27 weeks' gestation were treated with tocolysis and prophylactic antibiotics and delivered electively for lung maturity. The corrected perinatal survival was > 92%. The mean latency phase was 21.6 days (+/- 18.12 SD). Twenty-one percent of patients presented in labor; the mean latency phase for this subgroup was 14.4 (+/- 8.54) days. Nineteen patients (79%) had a latency phase > 7 days, and 14 (58%) had a latency phase > 14 days. Thirty-nine percent of infants required < 48 hours of mechanical ventilation. Six infants were delivered with intraventricular hemorrhage; in all cases it was grade 1 or 2. There were three (12.5%) postpartum infections and three septic neonates. Active expectant management using tocolysis and prophylactic antibiotics was associated with a prolonged latency phase, low infectious morbidity and good neonatal outcome.

MeSH terms

  • Adult
  • Ceftizoxime / therapeutic use*
  • Clinical Protocols
  • Decision Trees
  • Delivery, Obstetric / methods*
  • Drug Therapy, Combination
  • Female
  • Fetal Membranes, Premature Rupture / complications*
  • Fetal Membranes, Premature Rupture / diagnosis
  • Fetal Membranes, Premature Rupture / therapy*
  • Fetal Monitoring
  • Fetal Organ Maturity
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Magnesium Sulfate / therapeutic use*
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, Second
  • Prospective Studies
  • Terbutaline / therapeutic use*

Substances

  • Magnesium Sulfate
  • Ceftizoxime
  • Terbutaline