Novel HIV-inhibitory halistanol sulfates F-H from a marine sponge, Pseudoaxinissa digitata

J Nat Prod. 1994 Jan;57(1):164-7. doi: 10.1021/np50103a026.

Abstract

Three new steroid sulfates 2-4 related to halistanol sulfate [1] were isolated along with the known halistanol sulfate C [5] from the marine sponge Pseudoaxinissa digitata. Halistanol sulfates F [2] and G [3] proved to be cytoprotective against HIV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • HIV-1 / drug effects*
  • HIV-2 / drug effects*
  • Humans
  • Isomerism
  • Magnetic Resonance Spectroscopy
  • Porifera / chemistry*
  • Sterols / isolation & purification*
  • Sterols / pharmacology

Substances

  • Antiviral Agents
  • Sterols
  • halistanol trisulfate