Abstract
The V3 and V4 domains of human immunodeficiency virus type 2 (HIV-2) env genes from 14 rhesus macaques experimentally infected by HIV-2 SBL6669/H5 were sequenced. No variation was observed in viral sequences from sera and from uncultured peripheral blood mononuclear cells during primary infection. The first mutations were detected 17 months after infection; they mainly concerned the region between the V3 and V4 domains and not those domains themselves, which are known to be hypervariable, suggesting that variation of V3 is a late event of HIV infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines
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Animals
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Base Sequence
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Biological Evolution
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Clinical Trials as Topic
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Genes, env / genetics*
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HIV Envelope Protein gp120 / genetics*
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HIV Infections / blood*
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HIV Infections / prevention & control
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HIV-2 / genetics*
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Humans
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Immunization
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Leukocytes, Mononuclear / microbiology
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Longitudinal Studies
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Macaca fascicularis
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Macaca mulatta
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Macrophages / microbiology
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Molecular Sequence Data
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Mutagenesis*
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Sequence Analysis, DNA
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Sequence Homology, Nucleic Acid
Substances
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AIDS Vaccines
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HIV Envelope Protein gp120