Analysis of human growth hormone gene 5' sequences in isolated growth hormone deficiency patients

Y Wang; L L Yu; Q Sheng; C Meng; J Sun; S S Chen

doi:10.1136/jmg.31.1.81

Analysis of human growth hormone gene 5' sequences in isolated growth hormone deficiency patients

J Med Genet. 1994 Jan;31(1):81-2. doi: 10.1136/jmg.31.1.81.

Authors

Y Wang¹, L L Yu, Q Sheng, C Meng, J Sun, S S Chen

Affiliation

¹ Department of Biochemistry, Shanghai Second Medical University, PR China.

Abstract

Human growth hormone (hGH) gene deletion (6.7 to 7.6 kb) is one of the causes of isolated growth hormone deficiency (IGHD), named IGHD IA. IGHD IA, however, only accounts for about 10% of the total IGHD patients. Most IGHD is caused by unknown mechanisms. Here, hGH gene 5' sequences in three IGHD patients without hGH gene deletion were analysed to see if there was any mutation hindering the expression of the hGH gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Gene Expression
Growth Hormone / deficiency*
Growth Hormone / genetics*
Humans
Molecular Sequence Data
RNA, Messenger / genetics

Substances

RNA, Messenger
Growth Hormone