Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

J Antibiot (Tokyo). 1994 Feb;47(2):154-62. doi: 10.7164/antibiotics.47.154.

Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus fumigatus / chemistry
  • Magnetic Resonance Spectroscopy
  • Pyridines / chemistry*
  • Pyridines / isolation & purification
  • Pyridines / pharmacology*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Sterol O-Acyltransferase / antagonists & inhibitors*

Substances

  • Pyridines
  • Sesquiterpenes
  • pyripyropene A
  • pyripyropene B
  • pyripyropene C
  • pyripyropene D
  • Sterol O-Acyltransferase