Abstract
The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aspergillus fumigatus / chemistry
-
Magnetic Resonance Spectroscopy
-
Pyridines / chemistry*
-
Pyridines / isolation & purification
-
Pyridines / pharmacology*
-
Sesquiterpenes / chemistry*
-
Sesquiterpenes / isolation & purification
-
Sesquiterpenes / pharmacology*
-
Sterol O-Acyltransferase / antagonists & inhibitors*
Substances
-
Pyridines
-
Sesquiterpenes
-
pyripyropene A
-
pyripyropene B
-
pyripyropene C
-
pyripyropene D
-
Sterol O-Acyltransferase