Abstract
The effect of pretreatment with cimetidine (1 g day-1, 7 days) and of probenecid (1 g twice daily, 4 days) on the pharmacokinetics of tenoxicam (single oral dose, 20 mg) was studied in six healthy volunteers. Cmax was increased significantly when tenoxicam was given with probenecid (2.8 micrograms ml-1 alone, 3.5 micrograms ml-1 after probenecid; P < 0.005). No other pharmacokinetic parameters were altered significantly by either drug. It is concluded that neither cimetidine nor probenecid affects the pharmacokinetics of tenoxicam in a clinically important way.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / blood
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
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Cimetidine / pharmacology*
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Drug Interactions
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Female
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Humans
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Male
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Piroxicam / administration & dosage
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Piroxicam / analogs & derivatives*
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Piroxicam / blood
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Piroxicam / pharmacokinetics
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Probenecid / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Piroxicam
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Cimetidine
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Probenecid
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tenoxicam