1. Ergonomic interventions, which include the application of biomechanical models, are an integral part of a workplace injury control program. 2. The NIOSH 1991 Lifting Guide is an example of a biomechanical model. It is utilized as an assessment tool in the ergonomic analysis of a task performed by hospital nursing personnel. 3. The risk for musculoskeletal injury is quantified from the analysis. Economically feasible modifications to the task are outlined to reduce the associated lifting hazards.