Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility

J Med Chem. 1994 Mar 18;37(6):722-4. doi: 10.1021/jm00032a003.

Authors

M G Bock¹, R M DiPardo, E C Mellin, R C Newton, D F Veber, S B Freedman, A J Smith, S Patel, J A Kemp, G R Marshall, et al.

Affiliation

¹ Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486.

PMID: 8145220
DOI: 10.1021/jm00032a003

No abstract available

Publication types

Review

MeSH terms

Animals
Benzodiazepines / chemical synthesis*
Benzodiazepines / pharmacokinetics
Benzodiazepines / pharmacology*
Humans
Models, Biological
Receptors, Cholecystokinin / antagonists & inhibitors*
Receptors, Cholecystokinin / metabolism
Solubility

Substances

Receptors, Cholecystokinin
Benzodiazepines