Abstract
Hypersensitivity to topical hydrocortisone is becoming increasingly recognized. We present further evidence that this is mediated via a delayed-type hypersensitivity reaction. A hydrocortisone: albumin complex was able to induce a proliferative response in the peripheral blood mononuclear cells of patients allergic to hydrocortisone. Protein binding of hydrocortisone or a degradation product may be important in the development of corticosteroid allergy.
MeSH terms
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Administration, Cutaneous
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Cell Division
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Cells, Cultured
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Dermatitis, Allergic Contact / diagnosis
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Dermatitis, Allergic Contact / immunology*
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Drug Eruptions / diagnosis
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Drug Eruptions / immunology*
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Humans
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Hydrocortisone / adverse effects*
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Hydrocortisone / metabolism
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Hydrocortisone / pharmacology
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Hypersensitivity, Delayed / chemically induced*
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Hypersensitivity, Delayed / diagnosis
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Hypersensitivity, Delayed / immunology
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / immunology*
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Leukocytes, Mononuclear / pathology
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Protein Binding
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Serum Albumin / adverse effects
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Serum Albumin / pharmacology
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Thymidine
Substances
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Serum Albumin
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Thymidine
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Hydrocortisone