Elevated urinary excretion of endothelins in streptozotocin diabetic rats

E Morabito; N Corsico; S Serafini; E A Martelli

doi:10.1016/0024-3205(94)90168-6

Elevated urinary excretion of endothelins in streptozotocin diabetic rats

Life Sci. 1994;54(11):PL197-200. doi: 10.1016/0024-3205(94)90168-6.

Authors

E Morabito¹, N Corsico, S Serafini, E A Martelli

Affiliation

¹ Department of Pharmacology at R & D of Sigma-Tau S.p.A., Roma, Italy.

PMID: 8107516
DOI: 10.1016/0024-3205(94)90168-6

Abstract

Endothelin-1,2 urinary excretion, has been determined in control and streptozotocin diabetic rats at different times after diabetes induction. Diabetic rats showed increased urinary excretion of endothelins as compared to control rats, already three days after diabetes induction and up to 20 weeks.

MeSH terms

Animals
Diabetes Mellitus, Experimental / chemically induced
Diabetes Mellitus, Experimental / urine*
Endothelins / metabolism
Endothelins / urine*
Endothelium, Vascular / metabolism
Male
Rats
Rats, Brattleboro
Streptozocin

Substances

Endothelins
Streptozocin