Homology model building of the thyroid transcription factor 1 homeodomain

F Fogolari; G Esposito; P Viglino; G Damante; A Pastore

doi:10.1093/protein/6.5.513

Homology model building of the thyroid transcription factor 1 homeodomain

Protein Eng. 1993 Jul;6(5):513-9. doi: 10.1093/protein/6.5.513.

Authors

F Fogolari¹, G Esposito, P Viglino, G Damante, A Pastore

Affiliation

¹ Dipartimento di Scienze e Tecnologie Biomediche, Facoltà di Medicina, Università di Udine, Italy.

PMID: 8105464
DOI: 10.1093/protein/6.5.513

Abstract

A possible structure for the homeodomain of rat thyroid transcription factor 1 is proposed on the basis of the homology with other homeodomains whose structures have been solved by X-ray crystallography. A structure very similar to the reference ones is feasible and may account for the observed DNA-binding specificity. Structural features of the model, which are likely to be shared by other homeodomains, are discussed and may help researchers in the field to analyse their own experimental data.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Computer Simulation
DNA-Binding Proteins / chemistry*
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Genes, Homeobox* / genetics
Models, Molecular
Molecular Sequence Data
Nuclear Proteins / chemistry*
Nuclear Proteins / genetics
Nuclear Proteins / metabolism
Point Mutation
Protein Conformation
Sequence Deletion
Sequence Homology, Amino Acid*
Sequence Homology, Nucleic Acid
Structure-Activity Relationship
Thyroid Nuclear Factor 1
Transcription Factors / chemistry*
Transcription Factors / genetics
Transcription Factors / metabolism
X-Ray Diffraction

Substances

DNA-Binding Proteins
Nuclear Proteins
Thyroid Nuclear Factor 1
Transcription Factors