Abstract
Clinical use of eye drops of a hybrid beta-alpha-adrenoblocker OF-4680 to reduce intraocular pressure has shown a high efficacy of the drug, not inferior to thymolol, for local hypotensive therapy of open-angle glaucoma. A combination of thymolol with taurin helped reduce the inhibiting effect of the beta-blocker on chamber humor secretion and simultaneously enhanced its discharge. The results evidence the desirability of correcting glutathion deficiency, detected in the patients with narrow-angle glaucoma, by lipoic acid.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adrenergic beta-Antagonists / administration & dosage
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Adrenergic beta-Antagonists / adverse effects
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Animals
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Antioxidants / therapeutic use
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Drug Combinations
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Drug Evaluation
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Drug Evaluation, Preclinical
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Glaucoma, Open-Angle / drug therapy*
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Humans
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Intraocular Pressure / drug effects
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Ophthalmic Solutions
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Organic Chemicals
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Rabbits
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Taurine / therapeutic use
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Thymol / therapeutic use
Substances
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Adrenergic beta-Antagonists
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Antioxidants
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Drug Combinations
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OF 4647
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OF 4680
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Ophthalmic Solutions
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Organic Chemicals
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Taurine
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Thymol