Abstract
One- to 2-day-old chicks administered purified antichick Thy-1 IgG showed substantial amnesia for a single-trial passive discriminated avoidance task. Amnesia was clearly evident at 30 min after learning, during the intermediate stage of a three-stage model of memory processing, and persisted for at least 3 h. A similar effect was also observed with Fab and F(ab')2 fragments. Fc fragments, the non-IgG fraction of ascites, and saline yielded normal retention levels at all times. These results contrast with our earlier reports that both polyclonal and monoclonal antibodies to chick Thy-1 inhibited long-term memory formation only. The present findings are interpreted as possibly representing a dual effect of the purified IgG.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology
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Antigens, Surface / immunology
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Antigens, Surface / physiology*
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Ascitic Fluid / immunology
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Avoidance Learning / drug effects
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Avoidance Learning / physiology
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Brain / immunology
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Brain / physiology
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Chickens
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Color Perception / drug effects
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Color Perception / physiology
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Conditioning, Classical / drug effects
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Conditioning, Classical / physiology
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Immunoglobulin G / pharmacology*
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Isoantibodies / pharmacology*
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Membrane Glycoproteins / immunology
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Membrane Glycoproteins / physiology*
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Mental Recall / physiology*
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Retention, Psychology / physiology*
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Synaptic Membranes / immunology
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Synaptic Membranes / physiology
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Taste / drug effects
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Taste / physiology
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Thy-1 Antigens
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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Immunoglobulin G
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Isoantibodies
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Membrane Glycoproteins
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Thy-1 Antigens
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anti-Thy antibody