A dynamic numerical method for models of renal tubules

Bull Math Biol. 1994 May;56(3):547-65. doi: 10.1007/BF02460470.

Abstract

We show that an explicit method for solving hyperbolic partial differential equations can be applied to a model of a renal tubule to obtain both dynamic and steady-state solutions. Appropriate implementation of this method eliminates numerical instability arising from reversal of intratubular flow direction. To obtain second-order convergence in space and time, we employ the recently developed ENO (Essentially Non-Oscillatory) methodology. We present examples of computed flows and concentration profiles in representative model contexts. Finally, we indicate briefly how model tubules may be coupled to construct large-scale simulations of the renal counterflow system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Body Water / metabolism
  • Calculi*
  • Cell Membrane Permeability
  • Computer Simulation
  • Diuresis
  • Kidney Tubules / physiology*
  • Models, Biological*
  • Rheology*