New biomaterials through surface segregation phenomenon: new quaternary ammonium compounds as antibacterial agents

J Biomater Sci Polym Ed. 1994;5(6):607-19. doi: 10.1163/156856294x00239.

Abstract

Five new trisiloxane quaternary ammonium compounds were synthesized from hydrotrisiloxane with allyl glycidyl ether to yield the epoxy function. Various amines were then reacted to yield trisiloxane amines which were further reacted to methyl substitute or oxidize the beta-carbons in order to provide thermal stability. These new compounds were employed as melt additives in a nonwoven polypropylene fiber extrusion process to produce, through surface segregation, a new biomaterial with antibacterial properties.

MeSH terms

  • Amines / analysis
  • Anti-Bacterial Agents / chemical synthesis*
  • Biocompatible Materials / chemical synthesis*
  • Escherichia coli / drug effects
  • Quaternary Ammonium Compounds / chemical synthesis*
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / pharmacology
  • Siloxanes / chemical synthesis*
  • Siloxanes / chemistry
  • Siloxanes / pharmacology
  • Staphylococcus epidermidis / drug effects
  • Surface Properties

Substances

  • Amines
  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Quaternary Ammonium Compounds
  • Siloxanes