Successful adoptive immunotherapy with lymphokine-activated killer cells in the treatment of medulloblastoma disseminated via cerebrospinal fluid: case report

Neurosurgery. 1994 Jun;34(6):1078-80; discussion 1080-1. doi: 10.1227/00006123-199406000-00021.

Abstract

We report the case of a girl who developed cerebellar medulloblastoma at the age of 12 years and in whom, 4 years after surgical removal and radiotherapy, neoplastic dissemination via the cerebrospinal fluid took place. After only partially effective systemic and intrathecal chemotherapy, an intrathecal administration of lymphokine-activated killer cells and recombinant interleukin-2 allowed complete clinical recovery persisting after a follow-up of 30 months.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cell Line
  • Cerebellar Neoplasms / immunology
  • Cerebellar Neoplasms / therapy*
  • Child
  • Combined Modality Therapy
  • Cytotoxicity, Immunologic / immunology
  • Female
  • Follow-Up Studies
  • Glioblastoma
  • Humans
  • Immunotherapy, Adoptive*
  • Injections, Intraventricular
  • Interleukin-2 / administration & dosage
  • Killer Cells, Lymphokine-Activated / immunology
  • Killer Cells, Lymphokine-Activated / transplantation*
  • Male
  • Medulloblastoma / immunology
  • Medulloblastoma / therapy*

Substances

  • Interleukin-2