Polysialic acid expression in the salamander retina is inducible by thyroxine

Brain Res Dev Brain Res. 1994 May 13;79(1):140-6. doi: 10.1016/0165-3806(94)90059-0.

Abstract

Polysialylation of the neural cell adhesion molecule (NCAM) in the retina of Pleurodeles waltl is up-regulated during metamorphosis. Incubation of larvae in thyroxine permanently induced polysialic acid expression in the retina in a concentration-dependent but age-independent manner within 3 days of incubation (3 x 10(-7) M). Retinoic acid had no effect. This suggests direct hormonal regulation of a post-translational modification of NCAM in the amphibian retina.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism
  • Animals
  • Cell Adhesion Molecules, Neuronal / metabolism
  • Down-Regulation / drug effects
  • Larva
  • Pleurodeles
  • Polysaccharides / biosynthesis*
  • Protein Processing, Post-Translational
  • Retina / drug effects
  • Retina / growth & development
  • Retina / metabolism*
  • Sialic Acids / biosynthesis*
  • Thyroxine / pharmacology*
  • Tretinoin / pharmacology

Substances

  • Cell Adhesion Molecules, Neuronal
  • Polysaccharides
  • Sialic Acids
  • polysialic acid
  • Tretinoin
  • Thyroxine