Characterization of a cDNA encoding the precursor of platelet aggregation inhibition and metalloproteinase from Trimeresurus mucrosquamatus venom

Biochim Biophys Acta. 1994 Aug 18;1200(3):337-40. doi: 10.1016/0304-4165(94)90177-5.

Abstract

This paper presents the nucleotide sequence of a cDNA encoding a full-length precursor of a novel platelet aggregation inhibitor named trimucrin and a hemorrhagic metalloproteinase from Trimeresurus mucrosquamatus snake venom. The deduced structure of the precursor protein is compared with those of other members of the metalloproteinase/disintegrin family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Crotalid Venoms / genetics*
  • DNA, Complementary
  • Enzyme Precursors / genetics*
  • Metalloendopeptidases / genetics*
  • Molecular Sequence Data
  • Peptides / genetics*
  • Platelet Aggregation Inhibitors*
  • Sequence Homology, Amino Acid
  • Trimeresurus / genetics*

Substances

  • Crotalid Venoms
  • DNA, Complementary
  • Enzyme Precursors
  • Peptides
  • Platelet Aggregation Inhibitors
  • Trimeresurus venoms
  • trimucrin
  • Metalloendopeptidases

Associated data

  • GENBANK/X77089