Cervix uteri status was examined in 55 young nulliparous women in the course of triphasic oral contraception. The status of the cervix uteri was assessed on the basis of clinical, colposcopic, cytologic, and morphofunctional examinations. Triphase oral contraception with triregol was found conducive to the formation of squamous-cell metaplasia in ectopic sites, this promoting epithelialization of the cervix uteri.
PIP: The objective of this investigation was the study of clinical-morphological characteristics of the ecto- and endocervix in young nulliparous women with pseudoerosions in the course of using the 3-phase oral contraceptive (OC) Triregol made by Gedeon Richter Inc. of Hungary, which contains ethinyl estradiol and levonorgestrel. 55 healthy women, 17-30 years old, were observed. In the anamnesis of these women there was 1 instance of induced abortion and 1 instance of self-induced abortion. 22 women were married, and the rest were not. 2 patients had a history of inflammatory disease of the uterus and of the adnexa. In addition to routine clinical examination, echographic and dilatational colposcopy was performed in all women before starting them on the preparation. The observation was performed every 3, 6, 9, and 12 months and in the course of 1-2 months after taking the OC. A piece of tissue was taken by biopsy from the cervix and scrapings from the mucous membrane of the cervical canal for morphological examination. In 11 patients (27.5%) ectopia of varying extent was diagnosed by colposcopy, and in 27 patients (67.5%) ectopia in the transformation phase was discovered. Leukoplakia occurred in 2 patients (5%). Cervical biopsies were taken from 40 patients, and glandular pseudoerosion was discovered in 36, of whom in 18 patients fulminating and/or diffusive infiltration of lymphocytes were found in the subepithelial tissues, whereas papillary pseudoerosion was found in 2 cases. After 3 months of OC use in 2 patients full epithelization of the cervix was detected with multilayered flat epithelia. In the 2 patients with leukoplakia neither positive nor negative changes were observed. In 2 out of 40 patients a section of ripe or not ripe flat celled metaplasia in the mucous of the cervical canal and in 1 patient hyperplasia of the reserve cells were discovered. It must be underlined that in none of the observations was there a progressive pathological process nor the genesis of dysplasia detected.