Smoothing grouped bivariate data to obtain the incubation period distribution of AIDS

Stat Med. 1994 May 15;13(9):969-81. doi: 10.1002/sim.4780130907.

Abstract

We use a penalized likelihood approach to obtain a smooth estimate of a bivariate distribution from grouped data where each observation consists of a region in a plane. The purpose of the analysis is to estimate the incubation period distribution of AIDS from the Multicenter AIDS Cohort Study, a prevalent cohort of homosexual men. In this article we illustrate the usefulness of the penalized likelihood approach. We also discuss the use of a cross-validation and a Bayesian scheme to choose the smoothing parameters and bootstrap samples to assess uncertainty.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Serodiagnosis / statistics & numerical data
  • Acquired Immunodeficiency Syndrome / epidemiology*
  • Acquired Immunodeficiency Syndrome / transmission
  • Cohort Studies*
  • Confidence Intervals
  • Disease Outbreaks / statistics & numerical data*
  • Follow-Up Studies
  • Homosexuality
  • Humans
  • Los Angeles
  • Male
  • Models, Statistical*
  • Multicenter Studies as Topic / statistics & numerical data*
  • Reproducibility of Results