Abstract
This paper reports the synthesis and biological evaluation towards A1 and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic substituents in the 1 position. Some 1-benzyl-4-substituted amino derivatives were prepared and the cyclohexylamino-, anilino- and p-toluidino- derivatives showed an interesting moderately selective activity on the A1 receptor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cerebral Cortex / metabolism
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Chromatography, Gas
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Crystallography, X-Ray
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Conformation
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Neostriatum / metabolism
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Pyridazines / chemical synthesis*
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Pyridazines / chemistry
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Pyridazines / pharmacology
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Rats
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Receptors, Purinergic P1 / drug effects*
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Sheep
Substances
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Pyridazines
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Receptors, Purinergic P1