As many as 16 epileptic patients with the sings of sinistrality in the motor and sensory spheres were examined. The authors demonstrate the clinical characteristics of epilepsy in the left handed, that distinguish them from the right-handed; dissimilarity of each psychopathological symptom and syndrome to their analogs in the right-handed, the occurrence of unusual phenomena, impossible in the right-handed. Depict specific features of the EEG that distinguish the patients examined from healthy right- and left-handed. The data obtained are interpreted as evidence that the clinical characteristics and the EEG appearance of epilepsy are determined to a considerable measure by the profile of asymmetry of each patient as well as by the fact that the left-handed may demonstrate diverse varieties of functional brain asymmetry, differing from the type of asymmetry of cerebral hemisphere functions common to all the right-handed in the maintenance of integral neuropsychic activity.