Parapsoriasis in two children: a clinical, immunophenotypic, and immunogenotypic study

Pediatr Dermatol. 1994 Jun;11(2):151-5. doi: 10.1111/j.1525-1470.1994.tb00570.x.

Abstract

Parapsoriasis has been described rarely in childhood; a few reports mention this condition as preceding early mycosis fungoides. We report a boy age 15 and a girl age 8 years with different clinical features of parapsoriasis who were followed clinically and histologically for about four years. Immunophenotyping of the skin infiltrate and a T cell receptor gene rearrangement analysis were performed on each. The infiltrate was composed mainly of CD4+ and CD45+ lymphocytes in the first patient and of CD8+ and CD45+ in the second. No T cell receptor gene rearrangements were found. The paucity of knowledge about the evolution of this entity in childhood and its relationship to mycosis fungoides makes follow-up critical. The importance of immunophenotyping and immunogenotyping is particularly stressed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child
  • Female
  • Gene Rearrangement, T-Lymphocyte*
  • Humans
  • Immunophenotyping*
  • Male
  • Parapsoriasis / genetics
  • Parapsoriasis / immunology*
  • Parapsoriasis / pathology
  • Polymerase Chain Reaction