(S)-UH301, a silent 5-HT1A receptor antagonist, enhances plasma corticosterone levels in the rat

L Groenink; J van der Gugten; J Mos; R A Maes; B Olivier

doi:10.1016/0024-3205(94)00654-7

(S)-UH301, a silent 5-HT1A receptor antagonist, enhances plasma corticosterone levels in the rat

Life Sci. 1994;55(5):PL99-103. doi: 10.1016/0024-3205(94)00654-7.

Authors

L Groenink¹, J van der Gugten, J Mos, R A Maes, B Olivier

Affiliation

¹ Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, The Netherlands.

PMID: 8035646
DOI: 10.1016/0024-3205(94)00654-7

Abstract

The putative silent 5-HT1A receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT1A receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT1A-receptor agonistic effect of (S)-UH301, or reveals a hitherto unknown mechanism of action in (S)-UH301.

MeSH terms

8-Hydroxy-2-(di-n-propylamino)tetralin / analogs & derivatives*
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
Animals
Blood Glucose / analysis
Corticosterone / blood*
Dose-Response Relationship, Drug
Male
Rats
Rats, Wistar
Serotonin Antagonists*

Substances

Blood Glucose
Serotonin Antagonists
UH 301
8-Hydroxy-2-(di-n-propylamino)tetralin
Corticosterone