The aim of the study was to establish neonatal prognosis in cases of PROM onset in early pregnancy. Pregnancies included in a multicenter study. Group (E) are 16 pregnant women with PROM between 23 and 27 weeks of gestation. Group (D) are 22 pregnant women with PROM between 28 and 30 weeks of gestation. Group (E) women delivered between 24-36 weeks (x = 29.25 w; SE 0.92; confidence 95%: 27.2-31.2 w). 5/16 newborns died, two in the delivery room and three in the first days of life. Survival in this group was 11/16 (68.75%). 8/14 suffered from respiratory distress syndrome (RDS), severe in six. 2/14 newborns suffered from early onset sepsis and 6/14 intraventricular hemorrhage (IVH). Group (D) women delivered between 28-36 weeks (x 30.48 w; SE 0.38; confidence 95% 29.6-31.2 w. Only one newborn died from sepsis (Streptococcus agalactiae). Survival in this group was 21/22 (95.45%). 5/21 newborns suffered from RDS, severe only in one. Early onset sepsis in 2/22 and IVH 6/21. Infection has a high incidence in newborn infants with PROM. Mortality is related to respiratory distress syndrome. The most common problems are respiratory distress syndrome and intraventricular hemorrhage.