Unusual acantholytic bullous dermatosis associated with neoplasia and IgG and IgA antibodies against bovine desmocollins I and II

J Am Acad Dermatol. 1994 Aug;31(2 Pt 2):351-5. doi: 10.1016/s0190-9622(94)70171-7.

Abstract

There are unusual cases of pemphigus that have antibodies nonreactive with either pemphigus vulgaris or pemphigus foliaceus antigens. We describe a patient with an acantholytic bullous dermatosis and lung cancer with intercellular IgG and IgA antibodies that differed in specificity from those of pemphigus vulgaris and pemphigus foliaceus and reacted with bovine desmocollins I and II and recombinant desmocollin protein.

Publication types

  • Case Reports
  • Comparative Study
  • Review

MeSH terms

  • Adult
  • Animals
  • Antibody Specificity
  • Cattle
  • Desmocollins
  • Desmosomes / immunology*
  • Epidermolysis Bullosa / complications
  • Epidermolysis Bullosa / immunology*
  • Humans
  • Immunoglobulin A / analysis*
  • Immunoglobulin G / analysis*
  • Lung Neoplasms / complications*
  • Lung Neoplasms / immunology
  • Male
  • Membrane Glycoproteins / immunology*
  • Pemphigus / immunology
  • Recombinant Proteins / immunology

Substances

  • DSC1 protein, human
  • DSC2 protein, human
  • Desmocollins
  • Immunoglobulin A
  • Immunoglobulin G
  • Membrane Glycoproteins
  • Recombinant Proteins