Plasma beta-endorphin concentrations and analgesia-muscle relaxation in the newborn infant supported by mechanical ventilation

J Pediatr. 1994 Jul;125(1):113-6. doi: 10.1016/s0022-3476(94)70136-9.

Abstract

We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Female
  • Fentanyl / pharmacology
  • Fentanyl / therapeutic use*
  • Humans
  • Infant, Newborn
  • Male
  • Morphine / pharmacology
  • Morphine / therapeutic use*
  • Muscle Relaxation / drug effects
  • Pancuronium / pharmacology
  • Pancuronium / therapeutic use*
  • Prospective Studies
  • Respiration, Artificial / adverse effects
  • Respiratory Tract Diseases / therapy
  • Stress, Physiological / blood
  • Stress, Physiological / drug therapy*
  • Stress, Physiological / etiology
  • beta-Endorphin / blood*

Substances

  • beta-Endorphin
  • Morphine
  • Pancuronium
  • Fentanyl