Abstract
We evaluated the effects of pancuronium and opiates on plasma beta-endorphin concentrations in 25 infants supported by mechanical ventilation. Infants receiving opiate were randomly assigned to receive either fentanyl or morphine. There was no change in beta-endorphin concentrations after administration of pancuronium, whereas both fentanyl and morphine reduced beta-endorphin concentrations by approximately 60%.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Female
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Fentanyl / pharmacology
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Fentanyl / therapeutic use*
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Humans
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Infant, Newborn
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Male
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Morphine / pharmacology
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Morphine / therapeutic use*
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Muscle Relaxation / drug effects
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Pancuronium / pharmacology
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Pancuronium / therapeutic use*
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Prospective Studies
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Respiration, Artificial / adverse effects
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Respiratory Tract Diseases / therapy
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Stress, Physiological / blood
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Stress, Physiological / drug therapy*
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Stress, Physiological / etiology
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beta-Endorphin / blood*
Substances
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beta-Endorphin
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Morphine
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Pancuronium
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Fentanyl