Abstract
Methodology and the results of the in vitro membrane diffusion and in vivo bioavailability studies are presented. The results confirm a correlation between in vitro and in vivo findings. Hydrophilic macrogol-mixture with great molecular mass can be recommended as the optimal vehicle for formulation of diazepam suppositories.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biopharmaceutics
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Cyclodextrins
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Diazepam / administration & dosage*
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Diazepam / pharmacokinetics*
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Drug Compounding
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Excipients
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Male
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Polyethylene Glycols
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Rats
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Rats, Wistar
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Solubility
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Suppositories
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Suspensions
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beta-Cyclodextrins*
Substances
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Cyclodextrins
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Excipients
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Suppositories
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Suspensions
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beta-Cyclodextrins
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Polyethylene Glycols
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heptakis(2,6-O-dimethyl)beta-cyclodextrin
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polyethylene glycol monostearate
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Diazepam