In vivo versus in vitro assays for assessment of T- and B- cell function

M F Bachmann; T M Kündig

doi:10.1016/0952-7915(94)90108-2

In vivo versus in vitro assays for assessment of T- and B- cell function

Curr Opin Immunol. 1994 Apr;6(2):320-6. doi: 10.1016/0952-7915(94)90108-2.

Authors

M F Bachmann¹, T M Kündig

Affiliation

¹ Institute for Experimental Immunology, University of Zurich, Switzerland.

PMID: 8011216
DOI: 10.1016/0952-7915(94)90108-2

Abstract

As mice deficient in a particular gene provide an increasing number of novel in vivo models, in vivo assays that examine immune function are becoming a central issue. We found that the sensitivities of in vivo and in vitro assays are strikingly different. These differences have important implications for the interpretation and biological relevance of results.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
B-Lymphocytes / physiology*
Immunologic Tests / methods*
In Vitro Techniques
Mice
Mice, Knockout / immunology
Sensitivity and Specificity
T-Lymphocytes / physiology*
T-Lymphocytes, Cytotoxic / physiology
T-Lymphocytes, Helper-Inducer / physiology