Abstract
Neurolathyrism is a form of spastic paraparesis caused by the neuroexcitatory amino acid 3-N-oxalyl-L-2,3-diaminopropanoic acid (beta-ODAP) present in the seeds and foliage of Lathyrus sativus. The disease is irreversible and usually nonprogressive. Tolperisone HCl, a centrally acting muscle relaxant, has been shown to reduce significantly the spasticity in neurolathyrism patients. Sporadic occurrence of HTLV-1 infection (0.9%) and of osteolathyrism was found among the neurolathyrism patients. Osteolathyrism is linked to the consumption of the green shoots of Lathyrus sativus.
Publication types
-
Clinical Trial
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bangladesh
-
Bone Diseases / complications
-
HTLV-I Antibodies / blood
-
HTLV-I Antibodies / cerebrospinal fluid
-
Humans
-
Lathyrism / complications
-
Lathyrism / drug therapy*
-
Lathyrism / physiopathology
-
Motor Neuron Disease / drug therapy*
-
Motor Neuron Disease / physiopathology
-
Paraparesis, Tropical Spastic / drug therapy*
-
Paraparesis, Tropical Spastic / immunology
-
Paraparesis, Tropical Spastic / physiopathology
-
Tolperisone / therapeutic use*
Substances
-
HTLV-I Antibodies
-
Tolperisone