Clinical significance of the finding of subarachnoid blood on CT scan after head injury

Acta Neurochir (Wien). 1994;129(1-2):1-5. doi: 10.1007/BF01400864.

Abstract

The population analysed consisted of 268 out of 819 patients of a European nimodipine multicentre trial on severe head injury, whose first CT scan after injury showed signs of subarachnoid bleeding. The study demonstrated the importance of traumatic subarachnoid haemorrhage (tSAH) per se as a prognostic factor. The outcome of patients with tSAH is significantly worse than that of patients whose first CT does not show subarachnoid blood (noSAH). The outcome was unfavourable (dead, persistent vegetative state, severe disability) in 60% of tSAH patients compared to 30% of noSAH patients (p < 0.001). The difference in mortality was 42% vs. 14% (p < 0.001). The six month follow-up of tSAH patients complying with the study protocol and treated with intravenous nimodipine, 2 mg per hour for 7 days, showed a statistically significant reduction of unfavourable outcome from 66% to 51% (p < 0.05), compared to placebo treated patients.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Brain Damage, Chronic / diagnostic imaging
  • Brain Damage, Chronic / drug therapy
  • Brain Damage, Chronic / mortality
  • Brain Injuries / diagnostic imaging*
  • Brain Injuries / drug therapy
  • Brain Injuries / mortality
  • Disability Evaluation
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Europe
  • Female
  • Follow-Up Studies
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Neurologic Examination
  • Nimodipine / administration & dosage
  • Prospective Studies
  • Subarachnoid Hemorrhage / diagnostic imaging*
  • Subarachnoid Hemorrhage / drug therapy
  • Subarachnoid Hemorrhage / mortality
  • Survival Rate
  • Tomography, X-Ray Computed*

Substances

  • Nimodipine