A patient with multiple myeloma and respiratory insufficiency due to accumulation of paraprotein in the alveolar space

Br J Haematol. 1994 Jul;87(3):663-5. doi: 10.1111/j.1365-2141.1994.tb08338.x.

Abstract

We describe a patient with multiple myeloma and respiratory insufficiency. Autopsy revealed accumulation of IgG-kappa paraprotein in the alveolar space. The clinical and pathological presentation are typical for secondary pulmonary alveolar proteinosis. Attention is focussed on the possibility of secondary pulmonary alveolar proteinosis as a cause for dyspnoea in patients with haematological malignancies.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Immunoglobulin G / metabolism
  • Middle Aged
  • Multiple Myeloma / complications
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology*
  • Paraproteins / immunology
  • Paraproteins / metabolism*
  • Pulmonary Alveolar Proteinosis / complications
  • Pulmonary Alveolar Proteinosis / metabolism
  • Pulmonary Alveolar Proteinosis / pathology*
  • Pulmonary Alveoli / immunology
  • Pulmonary Alveoli / metabolism
  • Pulmonary Alveoli / pathology
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / metabolism
  • Respiratory Insufficiency / pathology*

Substances

  • Immunoglobulin G
  • Paraproteins